AustralieFrV1, Main, Exploration, bibRecord, 002F66

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Identifieur interne : 002F66 ( Main/Exploration ); précédent : 002F65; suivant : 002F67

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Auteurs : Meletios A. Dimopoulos [Grèce] ; Katja C. Weisel [Allemagne] ; Kevin W. Song [Canada] ; Michel Delforge [Belgique] ; Lionel Karlin [France] ; Hartmut Goldschmidt [Allemagne] ; Philippe Moreau [France] ; Anne Banos [France] ; Albert Oriol [Espagne] ; Laurent Garderet [France] ; Michele Cavo [Italie] ; Valentina Ivanova [Russie] ; Adrian Alegre [Espagne] ; Joaquin Martinez-Lopez [Espagne] ; Christine Chen [Canada] ; Andrew Spencer [Australie] ; Stefan Knop [Allemagne] ; Nizar J. Bahlis [Canada] ; Christoph Renner [Suisse] ; Xin Yu [États-Unis] ; Kevin Hong [États-Unis] ; Lars Sternas [États-Unis] ; Christian Jacques [États-Unis] ; Mohamed H. Zaki [États-Unis] ; Jesus F. San Miguel [Espagne]

Source :

Haematologica [ 0390-6078 ] ; 2015.

RBID : PMC:4591765

Descripteurs français

KwdFr :
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Dexaméthasone (administration et posologie), Estimation de Kaplan-Meier, Femelle, Humains, Myélome multiple (anatomopathologie), Myélome multiple (génétique), Myélome multiple (mortalité), Myélome multiple (traitement médicamenteux), Mâle, Pronostic, Protocoles de polychimiothérapie antinéoplasique (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Récidive, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Thalidomide (administration et posologie), Thalidomide (analogues et dérivés), Études de suivi.
MESH :
- administration et posologie : Dexaméthasone, Thalidomide.
- analogues et dérivés : Thalidomide.
- anatomopathologie : Myélome multiple.
- effets indésirables : Protocoles de polychimiothérapie antinéoplasique.
- génétique : Myélome multiple.
- mortalité : Myélome multiple.
- traitement médicamenteux : Myélome multiple.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Aberrations des chromosomes, Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Femelle, Humains, Mâle, Pronostic, Récidive, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Études de suivi.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (adverse effects), Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Chromosome Aberrations, Dexamethasone (administration & dosage), Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multiple Myeloma (drug therapy), Multiple Myeloma (genetics), Multiple Myeloma (mortality), Multiple Myeloma (pathology), Neoplasm Staging, Prognosis, Recurrence, Thalidomide (administration & dosage), Thalidomide (analogs & derivatives), Treatment Outcome.
MESH :
- chemical , administration & dosage : Dexamethasone, Thalidomide.
- adverse effects : Antineoplastic Combined Chemotherapy Protocols.
- chemical , analogs & derivatives : Thalidomide.
- drug therapy : Multiple Myeloma.
- genetics : Multiple Myeloma.
- mortality : Multiple Myeloma.
- pathology : Multiple Myeloma.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Aged, 80 and over, Chromosome Aberrations, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Staging, Prognosis, Recurrence, Treatment Outcome.

Abstract

Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had failed. At an updated median follow-up of 15.4 months, the progression-free survival was 4.0 versus 1.9 months (HR, 0.50; P<0.001), and median overall survival was 13.1 versus 8.1 months (HR, 0.72; P=0.009). Pomalidomide plus low-dose dexamethasone, compared with high-dose dexamethasone, improved progression-free survival in patients with del(17p) (4.6 versus 1.1 months; HR, 0.34; P <0.001), t(4;14) (2.8 versus 1.9 months; HR, 0.49; P=0.028), and in standard-risk patients (4.2 versus 2.3 months; HR, 0.55; P<0.001). Although the majority of patients treated with high-dose dexamethasone took pomalidomide after discontinuation, the overall survival of patients treated with pomalidomide plus low-dose dexamethasone or high-dose dexamethasone was 12.6 versus 7.7 months (HR, 0.45; P=0.008) in patients with del(17p), 7.5 versus 4.9 months (HR, 1.12; P=0.761) in those with t(4;14), and 14.0 versus 9.0 months (HR, 0.85; P=0.380) in standard-risk subjects. The overall response rate was higher in patients treated with pomalidomide plus low-dose dexamethasone than in those treated with high-dose dexamethasone both among standard-risk patients (35.2% versus 9.7%) and those with del(17p) (31.8% versus 4.3%), whereas it was similar in patients with t(4;14) (15.9% versus 13.3%). The safety of pomalidomide plus low-dose dexamethasone was consistent with initial reports. In conclusion, pomalidomide plus low-dose dexamethasone is efficacious in patients with relapsed/refractory multiple myeloma and del(17p) and/or t(4;14). This study is registered at ClinicalTrials.gov as NCT01311687 and with EudraCT as 2010-019820-30.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591765

DOI: 10.3324/haematol.2014.117077
PubMed: 26250580
PubMed Central: 4591765

Affiliations:

Allemagne, Australie, Belgique, Canada, Espagne, France, Grèce, Italie, Russie, Suisse, États-Unis
Alberta, Aquitaine, Attique (région), Bade-Wurtemberg, Catalogne, Communauté de Madrid, District de Karlsruhe, New Jersey, Nouvelle-Aquitaine, Pays de la Loire, Victoria (État), Île-de-France
Athènes, Barcelone, Bayonne, Calgary, Heidelberg, Madrid, Melbourne, Nantes, Paris
Université de Calgary

Le document en format XML

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<author><name sortKey="Yu, Xin" sort="Yu, Xin" uniqKey="Yu X" first="Xin" last="Yu">Xin Yu</name>
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<author><name sortKey="Hong, Kevin" sort="Hong, Kevin" uniqKey="Hong K" first="Kevin" last="Hong">Kevin Hong</name>
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<author><name sortKey="Zaki, Mohamed H" sort="Zaki, Mohamed H" uniqKey="Zaki M" first="Mohamed H." last="Zaki">Mohamed H. Zaki</name>
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<series><title level="j">Haematologica</title>
<idno type="ISSN">0390-6078</idno>
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<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p>Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone compared to high-dose dexamethasone among patients in whom bortezomib and lenalidomide treatment had failed. At an updated median follow-up of 15.4 months, the progression-free survival was 4.0 <italic>versus</italic>
 1.9 months (HR, 0.50; <italic>P</italic>
<0.001), and median overall survival was 13.1 <italic>versus</italic>
 8.1 months (HR, 0.72; <italic>P</italic>
=0.009). Pomalidomide plus low-dose dexamethasone, compared with high-dose dexamethasone, improved progression-free survival in patients with del(17p) (4.6 <italic>versus</italic>
 1.1 months; HR, 0.34; <italic>P</italic>
 <0.001), t(4;14) (2.8 <italic>versus</italic>
 1.9 months; HR, 0.49; <italic>P</italic>
=0.028), and in standard-risk patients (4.2 <italic>versus</italic>
 2.3 months; HR, 0.55; <italic>P</italic>
<0.001). Although the majority of patients treated with high-dose dexamethasone took pomalidomide after discontinuation, the overall survival of patients treated with pomalidomide plus low-dose dexamethasone or high-dose dexamethasone was 12.6 <italic>versus</italic>
 7.7 months (HR, 0.45; <italic>P</italic>
=0.008) in patients with del(17p), 7.5 <italic>versus</italic>
 4.9 months (HR, 1.12; <italic>P</italic>
=0.761) in those with t(4;14), and 14.0 <italic>versus</italic>
 9.0 months (HR, 0.85; <italic>P</italic>
=0.380) in standard-risk subjects. The overall response rate was higher in patients treated with pomalidomide plus low-dose dexamethasone than in those treated with high-dose dexamethasone both among standard-risk patients (35.2% <italic>versus</italic>
 9.7%) and those with del(17p) (31.8% <italic>versus</italic>
 4.3%), whereas it was similar in patients with t(4;14) (15.9% <italic>versus</italic>
 13.3%). The safety of pomalidomide plus low-dose dexamethasone was consistent with initial reports. In conclusion, pomalidomide plus low-dose dexamethasone is efficacious in patients with relapsed/refractory multiple myeloma and del(17p) and/or t(4;14). This study is registered at <ext-link ext-link-type="uri" xlink:href="ClinicalTrials.gov">ClinicalTrials.gov</ext-link>
 as NCT01311687 and with EudraCT as 2010-019820-30.</p>
</div>
</front>
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<name sortKey="Jacques, Christian" sort="Jacques, Christian" uniqKey="Jacques C" first="Christian" last="Jacques">Christian Jacques</name>
<name sortKey="Sternas, Lars" sort="Sternas, Lars" uniqKey="Sternas L" first="Lars" last="Sternas">Lars Sternas</name>
<name sortKey="Zaki, Mohamed H" sort="Zaki, Mohamed H" uniqKey="Zaki M" first="Mohamed H." last="Zaki">Mohamed H. Zaki</name>
</country>
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EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F66 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4591765
   |texte=   Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone
}}

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       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
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Serveur d'exploration sur les relations entre la France et l'Australie

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

Cytogenetics and long-term survival of patients with refractory or relapsed and refractory multiple myeloma treated with pomalidomide and low-dose dexamethasone

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	Serveur d'exploration sur les relations entre la France et l'Australie
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